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1.
Actual. SIDA. infectol ; 26(97 Suplemento 1): 26-40, 20180000. graf
Article in Spanish | LILACS, BINACIS | ID: biblio-1355033

ABSTRACT

Los tumores sólidos representan el 90% de las patologías oncohematológicas que se diagnostican en Argentina. Las infecciones son una de las complicaciones más frecuentes, causando una importante morbimortalidad, y en muchos casos retrasan la prosecución de los tratamientos específicos. La incidencia y tipo de infección depende del sitio específico del tumor, los fenómenos post obstructivos, el tipo e intensidad del tratamiento que se administre, las comorbilidades del paciente y la epidemiología local, entre otros factores. En forma constante se van incorporando nuevos tratamientos al arsenal terapéutico, tales como nuevos esquemas de quimioterapia, terapias blanco e inmunoterapia, y el manejo de las complicaciones asociadas a los mismos representa un desafío para el equipo tratante.En esta revisión abordamos la epidemiología, prevención y manejo de las complicaciones infecciosas más frecuentes en los pacientes con tumores de sistema nervioso central y de cabeza y cuello


Solid tumours represent 90 percent of the oncohematologic pathologies diagnosed in Argentina. Infections are one of the most frequent complications causing important morbidity and mortality and delay in prosecution of their specific treatment. The type of infection depends on the specific site of the tumour, the presence of post obstructive phenomena, the treatment administered, comorbidity and local epidemiology, among others. New therapies are being continuously incorporated to the armamentarium of cancer treatment such as new chemotherapies regimes, target therapy and immunotherapy. The management of adverse events and infectious complications associated with them are a challenge for the physician in charge of these patients.The epidemiology, prevention and management of the most frequent infectious complications in patients with tumours of the central nervous system and head and neck are reviewed in this paper


Subject(s)
Humans , Radiotherapy , General Surgery , Central Nervous System Infections/complications , Central Nervous System Neoplasms/prevention & control , Central Nervous System Neoplasms/epidemiology , Drug Therapy , Head and Neck Neoplasms/prevention & control , Head and Neck Neoplasms/epidemiology , Immunotherapy , Infections/complications
2.
Santiago; Ministerio de Salud; 2 ed; 2012. 52 p.
Non-conventional in Spanish | BIGG, LILACS | ID: biblio-948198

ABSTRACT

Objetivo general: generar recomendaciones basadas en la mejor evidencia disponible acerca del manejo de personas con tumores primarios del sistema nervioso central o que hayan sido tratados por ello. Objetivos específicos: personas con tumores primarios del sistema nervioso central o que hayan sido tratados por ello, que reciben atención en el nivel secundario y nivel terciario de salud en el sector público y privado de salud. Usuarios de la guía: Médicos Generales, de Urgencia, Neurólogos, Neurocirujanos, Oncólogos, Radioterapeutas, y otros médicos y profesionales que participan en la atención integral de los pacientes con tumores primarios del sistema nervioso central o tratados por ello.


Subject(s)
Humans , Adolescent , Young Adult , Central Nervous System Neoplasms/diagnosis , Nervous System Neoplasms/therapy , Primary Prevention , Mass Screening , Central Nervous System Neoplasms/prevention & control
3.
São Paulo med. j ; 125(5): 286-288, Sept. 2007.
Article in English | LILACS | ID: lil-470626

ABSTRACT

Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1 percent of all non-Hodgkin's lymphoma, 2 percent of all extranodal lymphomas and 5 percent of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eighty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38 percent), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.


O linfoma primário do testículo (LPT) foi descrito como uma entidade clínica pela primeira vez em 1866. É uma doença rara e corresponde a 1 por cento de todos os linfomas não-Hodgkin, 2 por cento de todos os linfomas extranodais e 5 por cento de todos as neoplasias testiculares. É o tumor testicular mais comum em homens entre 60 e 80 anos de idade. LPT é único em sua elevada incidência de envolvimento bilateral (8-38 por cento), sendo o tumor testicular bilateral mais comum. Tem uma predileção por disseminação para regiões extranodais não-contíguas, especialmente para o sistema nervoso central (SNC). Estágios avançados da doença são usualmente tratados com quimioterapia à base de doxorubicina. Para os estágios mais precoces, as opiniões são divergentes quanto à quimioterapia associada à orquiectomia. A alta prevalência de disseminação, especialmente para o SNC, sugere o uso de quimioterapia intratecal como profilaxia. Estudos prospectivos multicêntricos incluindo um grande número de pacientes poderiam resolver a questão com relação ao manejo deste subtipo de linfoma não-Hodgkin.


Subject(s)
Humans , Male , Lymphoma, Non-Hodgkin/therapy , Testicular Neoplasms/therapy , Central Nervous System Neoplasms/prevention & control , Doxorubicin/therapeutic use , Lymphoma, Non-Hodgkin/complications , Lymphoma, Non-Hodgkin/etiology , Orchiectomy , Testicular Neoplasms/complications , Testicular Neoplasms/etiology , Time Factors
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